Clinical Trial: Debridement, Antibiotics and Implant Retention in Early Periprosthetic Joint Infection: A Retrospective Cohort Study

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Debridement, Antibiotics and Implant Retention in Early Periprosthetic Joint Infection: A Retrospective Cohort Study

Brief Summary: Introduction: Periprosthetic joint infection (PJI) is a common cause for reoperation after knee and hip arthroplasty surgery. Debridement, antibiotics and implant retention (DAIR) is recommended in early infections (< 4 weeks) and stable implants. Aims: To define the success rate of DAIR in early infections and to identify predictors for success. Material and methods: In a retrospective cohort study we included patients with hip- or knee arthroplasties reoperated for an early PJI at Danderyd Hospital 2007-2012. Logistic regression analysis was used to identify risk factors affecting success rate. Primary outcome variable was the success of the DAIR treatment. Secondary outcome variable vas risk factors for treatment failure.

Detailed Summary:
Sponsor: Danderyd Hospital

Current Primary Outcome: Successful treatment [ Time Frame: 6 year ]

The success rate, in terms of infection eradication without additional surgical methods, of debridement, antibiotics and implant retention in early postoperative periprosthetic joint infection..


Original Primary Outcome: Same as current

Current Secondary Outcome: Risk factors for treatment failure [ Time Frame: 6 year ]

Analyze of potential risk factors for treatment failure, age, gender, comorbidities i.e type 1 or 2 diabetes mellitus, renal insufficiency, dementia, systemic inflammatory disease, local or systemic infection, American Society of Anesthesiologists classification, virulence of infecting microbial, hospital stay, typ of arthroplasty, revision arthroplasty, and administration of antibiotics prior to debridement, antibiotics and implant retention treatment.


Original Secondary Outcome: Same as current

Information By: Danderyd Hospital

Dates:
Date Received: March 6, 2014
Date Started: January 2013
Date Completion:
Last Updated: March 8, 2014
Last Verified: March 2014