Clinical Trial: Pathophysiology of Orthostatic Intolerance
Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional
Official Title: Pathophysiology of Orthostatic Intolerance
Brief Summary: The purpose of this study is to describe the mechanism of orthostatic intolerance, relying on cardiovascular physiological studies. The syndrome is of undetermined etiology, but the syndrome causes impairment of a number of young adults, females more than males, with symptoms of tachycardia, fatigue, lightheadedness, palpitations, blurred vision, chest discomfort, difficulty concentrating, and dizziness with the upright posture. It is believed that many different pathophysiological processes can give rise to this disorder.
Detailed Summary:
Sponsor: Satish R. Raj
Current Primary Outcome: Physiological abnormalities in orthostatic intolerance [ Time Frame: 1 day ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
- blood volume [ Time Frame: 1 day ]
- intrinsic heart rate [ Time Frame: 1 hour ]
- quantitative sweat testing [ Time Frame: 2 hours ]
- residual sympathetic function after pharmacological autonomic blockade [ Time Frame: 3 hours ]
- norepinephrine spillover [ Time Frame: 3 hours ]
Original Secondary Outcome: Same as current
Information By: Vanderbilt University Medical Center
Dates:
Date Received: January 22, 2008
Date Started: December 1996
Date Completion: December 2018
Last Updated: March 22, 2017
Last Verified: March 2017
