Clinical Trial: Acute Salt Handling in Orthostatic Intolerance

Study Status: Active, not recruiting
Recruit Status: Active, not recruiting
Study Type: Interventional

Official Title: Acute Renal Salt Handling in Orthostatic Intolerance

Brief Summary: The investigators will test the hypothesis that patients with chronic orthostatic intolerance or postural orthostatic tachycardia syndrome (OI or POTS) will be unable to conserve urinary sodium as compared to healthy control subjects.

Detailed Summary: Patients with chronic OI appear to be hypovolemic with abnormalities in hormones that regulate salt & water handling. Increases in dietary salt have salutary effects on orthostatic tolerance in a physiological laboratory. The infusion of intravenous saline acutely decreased heart rate in this patient population. Preliminary data from Vanderbilt suggests abnormal salt handling in patients with chronic OI in a few patients. These data need to be confirmed and a better understanding of sodium handling in response to acute salt loads is required in these patients.
Sponsor: Vanderbilt University

Current Primary Outcome: Urinary Na excretion [ Time Frame: 24h and then hourly post saline load ]

Original Primary Outcome: Same as current

Current Secondary Outcome: Catecholamine levels [ Time Frame: 1 day ]

Original Secondary Outcome: Same as current

Information By: Vanderbilt University Medical Center

Dates:
Date Received: December 22, 2007
Date Started: February 2007
Date Completion: December 2018
Last Updated: March 22, 2017
Last Verified: March 2017