Clinical Trial: Exercise Versus Diet in the Treatment of Nonalcoholic Fatty Liver Disease
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: Exercise Versus Diet in the Treatment of Nonalcoholic Fatty Liver Disease
Brief Summary:
The central hypothesis of this proposal is that a reduction in hepatic mitochondrial function is the main pathophysiology behind NAFLD (Non-Alcoholic Fatty Liver Disease) and NASH (Non alcoholic steatohepatitis). The investigators further hypothesize that lifestyle modifications through aerobic exercise training without weight loss or diet-induced weight loss are effective in reducing NAFLD parameters by improving hepatic mitochondrial content and function in human subjects.
The investigators propose a randomized, controlled human clinical trial to compare the effects of aerobic exercise training (without weight loss) versus diet-induced weight loss (without exercise) in individuals who have NAFLD or liver biopsy-confirmed NASH
Detailed Summary:
Fatty Liver Disease) and NASH (Non alcoholic steatohepatitis). The investigators further hypothesize that lifestyle modifications through aerobic exercise training without weight loss or diet-induced weight loss are effective in reducing NAFLD parameters by improving hepatic mitochondrial content and function in human subjects.
The investigators propose a randomized, controlled human clinical trial to compare the effects of aerobic exercise training (without weight loss) versus diet-induced weight loss (without exercise) in individuals who have NAFLD or liver biopsy-confirmed NASH
Sponsor: University of Missouri-Columbia
Current Primary Outcome: NASH ( Non alcoholic steatohepatitis score) on liver biopsy [ Time Frame: baseline and 24 weeks ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
- Liver Function Tests [ Time Frame: Baseline and 24 weeks ]ALT/AST.
- DXA Scan [ Time Frame: Baseline and 24 weeks ]
- Ultrasonographical changes in liver echotexture [ Time Frame: Baseline and 24 weeks ]
Original Secondary Outcome: Same as current
Information By: University of Missouri-Columbia
Dates:
Date Received: November 8, 2010
Date Started: October 2010
Date Completion:
Last Updated: October 3, 2016
Last Verified: October 2016