Clinical Trial: Purified Anthocyanin and Nonalcoholic Fatty Liver Disease

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Effects of Purified Anthocyanin on Oxidative and Inflammatory Markers in Subjects With Nonalcoholic Fatty Liver Disease: A Randomized, Double-Blinded, Placebo-Controlled T

Brief Summary: Oxidative stress and inflammation are involved in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Anthocyanins from different plant foods have been shown to improve features of experimental NASH, such as oxidative stress, dyslipidemia, liver steatosis, and inflammation in rodents. The purpose of this study is to investigate whether purified anthocyanin supplementation beneficially alters oxidative, inflammatory, and apoptotic biomarkers in adults with features of NAFLD.

Detailed Summary:
Sponsor: Shaoguan University

Current Primary Outcome: Biomarkers related to oxidative stress [ Time Frame: Twelve weeks ]

plasma total antioxidant capacity; plasma levels of protein carbonyl groups


Original Primary Outcome: Same as current

Current Secondary Outcome: Biomarkers related to inflammation [ Time Frame: Twelve weeks ]

tumor necrosis factor alpha; interleukin-8; high sensitive C-reactive protein


Original Secondary Outcome: Same as current

Information By: Shaoguan University

Dates:
Date Received: September 2, 2013
Date Started: June 2013
Date Completion:
Last Updated: July 31, 2014
Last Verified: July 2014