Clinical Trial: The Value of Diagnosis and Outcome Prediction in CTC for Metastatic NPC Patients

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Using Circulating Tumor Cells to Diagnose and Predict Prognosis in Metastatic Nasopharyngeal Carcinoma Patients

Brief Summary: A circulating tumor cell (CTC) count is an established prognostic factor in some malignancies such as metastatic breast cancer. However, the value of CTC in diagnosis and outcome prediction of metastatic nasopharyngeal carcinoma (mNPC) patients is not unknown. Through the observational prospective clinical trial, sensitivity, specificity, positive and negative predictive values of CTC in diagnosis of mNPC patients will be gained. Further, the value of CTC in outcome prediction of mNPC patients will be uncovered.

Detailed Summary:
Sponsor: Sun Yat-sen University

Current Primary Outcome: Overall survival rate [ Time Frame: 3 years ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

• The proportion of positives that are correctly identified as such [ Time Frame: 3 years ]
  number of true positives divided by (number of true positives plus number of false negatives)
• The proportion of negatives that are correctly identified as such [ Time Frame: 3 years ]
  number of true negatives divided by (number of true negatives plus number of false positives)
• The proportions of positive results in statistics and diagnostic tests that are true positive results. [ Time Frame: 3 years ]
  number of true positives divided by number of positive calls
• The proportions of negative results in statistics and diagnostic tests that are true negative results. [ Time Frame: 3 years ]
  number of true negatives divided by number of negative calls

Original Secondary Outcome: Same as current

Information By: Sun Yat-sen University

Dates:
Date Received: July 20, 2015
Date Started: December 2014
Date Completion:
Last Updated: August 25, 2016
Last Verified: August 2016