Clinical Trial: Marijuana Cue-Reactivity & Seeking Behavior in Regular Cannabis Users
Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional
Official Title: Marijuana Cue-Reactivity & Seeking Behavior in Regular Cannabis Users: A Pilot Test of Glutamatergic Modulation
Brief Summary: The purpose of the proposed study is to examine the relationship between marijuana reminders, or "cues", craving for marijuana, and marijuana use. The principal investigator is also assessing whether N-acetylcysteine, can reduce marijuana craving or use.
Detailed Summary:
This study involves three screening sessions that could last about 3 hours each.
Part of this study will be conducted on an inpatient unit where the participant will live for 4 straight nights.
During the inpatient stay participants will participant in experimental sessions where they will be asked to smoke cigarettes containing either marijuana or placebo (a blank). Participants will be asked to take capsules that could contain N-acetylcysteine or placebo (blank).
Participants will be asked to complete questionnaires and you will have your vital signs (blood pressure, heart rate) monitored.
Sponsor: Wayne State University
Current Primary Outcome:
- Marijuana Craving Visual Analog Scale (VAS) (Self-report measure) [ Time Frame: Change is being assessed. Marijuana Craving VAS administered at baseline 0900, at 0930, 1000, 1030, 1100, 1230, 1250, 1310, 1320, 1330, 1345, 1400, 1430, 1500, 1530, and 1600. ]
- Marijuana Craving Questionnaire (Self-report measure) [ Time Frame: Change is being assessed. Marijuana Craving Quest.administered at baseline 0900, at 0930, 1000, 1030, 1100, 1230, 1345, 1400, 1430, 1500, 1530, and 1600. ]
- Marijuana Rating Form (Self-report measure) [ Time Frame: Change is being assessed. Marijuana Rating Form administered at baseline 0900, at 0930, 1000, 1030, 1100, 1230, 1345, 1400, 1430, 1500, 1530, and 1600. ]
- Subjective Effects Scale Visual Analog Scale (VAS) (Self-report measure) [ Time Frame: Change is being assessed. Subjective Effects Scale administered at baseline 0900, at 0930, 1000, 1030, 1100, 1230, 1345, 1400, 1430, 1500, 1530, and 1600. ]
- Questionnaire of Smoking Urges (Self-report measure) [ Time Frame: Change is being assessed. Questionnaire is administered at baseline 0900, at 0930, 1000, 1030, 1100, 1230, 1345, 1400, 1430, 1500, 1530, and 1600. ]
- Marijuana Withdrawal Checklist [ Time Frame: Change is being assessed. Questionnaire is administered at baseline 0900, at 0930, 1000, 1030, 1100, 1230, 1345, 1400, 1430, 1500, 1530, and 1600. ]
- NAC Side Effect Checklist [ Time Frame: Change is being assessed. Questionnaire is administered at baseline 0900, at 0930, 1000, 1030, 1100, 1230, 1345, 1400, 1430, 1500, 1530, and 1600. ]
- Systolic bl
Original Primary Outcome: Same as current
Current Secondary Outcome:
Original Secondary Outcome:
Information By: Wayne State University
Dates:
Date Received: April 25, 2017
Date Started: May 2017
Date Completion: May 2019
Last Updated: May 12, 2017
Last Verified: May 2017