Clinical Trial: Impact of Endothelial Cell Activation and Modifications of Haemostasis Induced by Infective Endocarditis on the Risk of Embolism
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: Impact of Endothelial Cell Activation and Modifications of Haemostasis Induced by Infective Endocarditis on the Risk of Embolism.
Brief Summary: Prospective study including all the consecutive patients admitted at the Department of Cardiology, Timone Hospital wih a definite diagnosis of IE according to the modified Duke criteria. The period of inclusion will be for 24 months. Eighty patients and age-matched control subject will be included. Primary end point are EE occurring during the antimicrobial treatment and secondary end points will be 6-month mortality, vegetation length and the impact of antimicrobial treatment on inflammation-induced procoagulant changes and endothelial cell activation.
Detailed Summary:
Sponsor: Assistance Publique Hopitaux De Marseille
Current Primary Outcome: Embolic events occurring during the antimicrobial treatment a [ Time Frame: 30 months ]
Original Primary Outcome: Same as current
Current Secondary Outcome: Will be 6-month mortality, vegetation length and the impact of antimicrobial treatment on inflammation-induced procoagulant changes and endothelial cell activation. [ Time Frame: 30months ]
Original Secondary Outcome: Same as current
Information By: Assistance Publique Hopitaux De Marseille
Dates:
Date Received: January 15, 2009
Date Started: September 2008
Date Completion:
Last Updated: August 21, 2015
Last Verified: May 2010