Clinical Trial: Effects of Levothyroxine on Endothelial Function of Patients With Subclinical Hypothyroidism
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: Effects of Levothyroxine on Endothelial Function of Patients With Subclinical Hypothyroidism
Brief Summary: Hypothyroidism is risk factor in atherosclerotic cardiovascular diseases, but there is a controversy in effect of subclinical hypothyroidism on cardiovascular diseases. We aim to estimate the relation between subclinical hypothyroidism and endothelial dysfunction and the effects of levothyroxine therapy on it. Patients with confirmed subclinical hypothyroidism by lab results will be randomized to two groups of treatment with one daily dose of 100 mg Levothyroxine or placebo. The flow-mediated dilation and intima media thickness are evaluated before and after the study.
Detailed Summary:
Sponsor: Isfahan University of Medical Sciences
Current Primary Outcome:
- Change from baseline flow-mediated dilation at 2 months [ Time Frame: At baseline and then 2 months after treatment ]Flow-mediated dilation will be assessed using standard method with a radiologist unaware to the study arms at baseline and then 2 months after treatment.
- Change from baseline intima-media thickness at 2 months [ Time Frame: At baseline and then 2 months after treatment ]Intima-media thickness will be assessed using standard method with a radiologist unaware to the study arms at baseline and then 2 months after treatment.
Original Primary Outcome: Same as current
Current Secondary Outcome:
Original Secondary Outcome:
Information By: Isfahan University of Medical Sciences
Dates:
Date Received: March 12, 2014
Date Started: May 2013
Date Completion:
Last Updated: March 17, 2014
Last Verified: March 2014
