Clinical Trial: Effects of L-carnitine on Hypothyroidism

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Single-center, Randomized, Double-Blinded, Comparative Study of the Effectiveness of L-carnitine in Patients'Fatigue Degree Changing With Hypothyroidism Who Take Levothyro

Brief Summary: L-carnitine and thyroid hormone tended to antagonize reciprocally in human body. Urinary excretion of L-carnitine decreased in hypothyroid patients, and levothyroxine supplementation increased excretion of L-carnitine. The investigators hypothesized that supplying L-carnitine to hypothyroid patients with fatigue symptom could improve the quality of life, and fatigue score in them. Therefore, the investigators planned to compare the efficacy of L-carnitine and placebo in hypothyroid patients who had taken levothyroxine.

Detailed Summary:
Sponsor: Korea University Anam Hospital

Current Primary Outcome: Fatigue Severity scale [ Time Frame: baseline and 12 weeks ]

Change from Baseline in Fatigue severity scale at 12 weeks (scoring `fatigue severity scale` at baseline and 12 weeks)


Original Primary Outcome: Same as current

Current Secondary Outcome: Wessely and Powell score [ Time Frame: baseline and 12 weeks ]

Change from Baseline in Wessely and Powell score at 12 weeks (scoring `Wessely and Powell score` at baseline and 12 weeks)


Original Secondary Outcome: Same as current

Information By: Korea University Anam Hospital

Dates:
Date Received: January 10, 2013
Date Started: August 2012
Date Completion:
Last Updated: December 2, 2013
Last Verified: December 2013