Clinical Trial: Efficacy of Midodrine for the Prevention of Orthostatic Hypotension During Early Mobilization After Fast-track Hip Arthroplasty
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: Efficacy of Midodrine for the Prevention of Orthostatic Hypotension During Early Mobilization After Fast-track Hip Arthroplasty - a Randomized, Placebo Controlled Trial.
Brief Summary: The aim of this study is to examine the efficacy of 5 mg Midodrine (Gutron) vs. placebo on reducing the incidence of orthostatic hypotension during mobilization 6 h after a total hip arthroplasty.
Detailed Summary:
Sponsor: Rigshospitalet, Denmark
Current Primary Outcome: Orthostatic hypotension [ Time Frame: 6 hours after surgery ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
- Orthostatic hypotension 24 hours after surgery [ Time Frame: 24 hours after end of surgery. ]
- Orthostatic Intolerance [ Time Frame: 6 and 24 hours after end of surgery ]Orthostatic intolerance is defined as subjective presyncopal symptoms (dizziness, nausea etc.) during mobilization after surgery
- Treatment side effects [ Time Frame: 6 and 24 hours after end of surgery ]
The following side effects to Midodrine are evaluated:
- Pruritus
- Headache
- Supine hypertension
- Urinary retention
Original Secondary Outcome: Same as current
Information By: Rigshospitalet, Denmark
Dates:
Date Received: October 10, 2012
Date Started: October 2012
Date Completion:
Last Updated: January 17, 2014
Last Verified: January 2014