Clinical Trial: Long Term Outcome of Hypospadias Repair

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Long Term Outcome of Hypospadias Repair: A Comparative Study

Brief Summary: Hypospadias is a common congenital abnormality of the penis which affects approximately 1 boy in 250. The opening of the urethra is located on the undersurface of the penis rather than the tip,the foreskin is deficient and there is curvature of the penile shaft in more severe cases. Although the most commonly practised corrective operation ( TIP procedure) gives generally good results, recently published evidence points to a possible long term risk of stenosis ( narrowing of the reconstructed urethra). This comparative study will combine clinical assessment with non invasive measurements of urinary flow to assess the functional outcome of a large series of patients who have undergone hypospadias surgery . The study is primarily designed to answer this question : does a modification of the standard operation which incorporates a skin graft into the reconstructed urethra lead to improved urinary flow and a decreased risk of stenosis? This has not been previously studied . The findings of our study could make an important contribution to improvements in the surgical treatment of boys born with hypospadias.

Detailed Summary:
Sponsor: The Leeds Teaching Hospitals NHS Trust

Current Primary Outcome: Does a modification of the standard TIP hypospadias operation which incorporates a skin graft into the reconstructed urethra result in improved urinary flow and a (presumed)decrease in the long term risk of stenosis? [ Time Frame: 1 year ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: The Leeds Teaching Hospitals NHS Trust

Dates:
Date Received: November 20, 2013
Date Started: October 2012
Date Completion:
Last Updated: April 3, 2014
Last Verified: April 2014