Clinical Trial: Bioimpedance Spectroscopy for the Differential Diagnosis of Hyponatremia

Study Status: Completed
Recruit Status: Completed
Study Type: Observational [Patient Registry]

Official Title: Bioimpedance Spectroscopy for the Differential Diagnosis of Hyponatremia

Brief Summary: We aimed to investigate the role of bioimpedance spectroscopy for the diagnosis of hyponatremia

Detailed Summary:

  • Up to now, "Hyponatremia" differentially diagnosed by physical examination, plasma and urine osmolalities, Echocardiography and biochemical measurements.
  • The purpose of this study is to determine whether bioimpedance spectroscopy can be used for the detection of hypovolemia and hypervolemia for the differential diagnosis of hyponatremia.

Sponsor: Zonguldak Karaelmas University

Current Primary Outcome: Accuracy of volume status measured by bioimpedance spectroscopy [ Time Frame: Six months ]

BIOIMPEDANCE SPECTROSCOPY:

Overhydration (OH) measurement by Body Composition Monitor (Fresenius Medical Care)

Negative values of "OH" indicating Hypovolemia and positive values for hypervolemia in hyponatremic patients.



Original Primary Outcome: Same as current

Current Secondary Outcome: Laboratory data and echocardiography [ Time Frame: 6 Months ]

LABORATORY MEASUREMENTS Hemoglobin, Hematocrit, White blood cell count Platelet count, Na, Potassium, Chlorur, Urea, Creatinine, Uric acid, Plasma osmolality, Urine osmolality, Alanine transaminase , Aspartate transaminase , Urine specific gravity,

TREATMENT MODALITY

  1. Diuretics
  2. Intravenous hydration by isotonic saline

ECHOCARDIOGRAPHY:

Left ventricular end-diastolic diameter, Left ventricular end-systolic diameter, Ejection fraction(%), Left Atrium diameter, Aortic diameter, Right atrium diameter, Interventricular septum, Posterior wall thickness, Mitral insufficiency, Pulmonary insufficiency, Systolic pulmonary artery pressure, Tricuspid insufficiency



Original Secondary Outcome: Same as current

Information By: Zonguldak Karaelmas University

Dates:
Date Received: April 20, 2013
Date Started: February 2013
Date Completion:
Last Updated: October 30, 2014
Last Verified: October 2014