Clinical Trial: Hyperventilation Versus Exercise Testing Sensitivity in Exercise Induced Asthma

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional

Official Title: Hyperventilation Versus Exercise Testing Sensitivity in Exercise Induced Asthma

Brief Summary: The diagnosis of exercise-induced bronchospasm (EIB) is difficult. The metacholine challenge test is not enough specific for the diagnosis of EIB. The exercise challenge test on a cycle ergometer is often use to diagnose this condition. This test has very high specificity, but not enough sensibility because the ventilation achieved during this test is often not big enough to induce a bronchospasm, especially in trained athletes. Eucapnic voluntary hyperventilation (EVH) is the recommended test of the Olympic National committee to establish the diagnosis of EIB, but there are no study comparing the sensibility and specificity of the cycle ergometer challenge test and the isocapnic hyperventilation in an establish population of asthmatics. The investigators assume that the sensitivity and specificity of EVH are higher than those of the cycle ergometer for the diagnosis of EIB in a population of asthmatics with symptoms suggestive of bronchospasm on exertion. In a population of asthmatics with exercise symptoms, what is the sensitivity and specificity of EVH and exercise challenge on a cycle ergometer for the diagnosis of EIB?

Detailed Summary:
Sponsor: Université de Sherbrooke

Current Primary Outcome: Compare the sensitivity and specificity of eucapnic voluntary hyperventilation versus exercise challenge testing on a cycle ergometer for exercise-induced bronchospasm diagnosis in established asthmatic subjects with exercise symptoms. [ Time Frame: through study completion, an average of 1 month ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

• Correlate the magnitude of exercise bronchoconstriction during EVH and exercise challenge testing on a cycle ergometer (measurement of FEV1 before and after these tests) with severity of symptoms of EIB (with questionnaires) [ Time Frame: through study completion, an average of 1 month ]
  The questionnaires for the severity of symptoms of EIB will include a modified Borg questionnaire, symptoms of EIB after the tests and usual symptoms of EIB after a vigorous effort.
• Correlate the magnitude of exercise bronchoconstriction during EVH and exercise challenge testing on a cycle ergometer (FEV1 before and after these tests) with severity of bronchial hyperreactivity evaluated by methacholine challenge test (MCT). [ Time Frame: through study completion, an average of 1 month ]
  severity of bronchial hyperreactivity evaluated by methacholine challenge test (MCT) will be measured with the provocative concentration causing a 20% fall in FEV1 (PC20) (mg/ml) as recommended by the American Thoracic Society (ATS).

Original Secondary Outcome: Same as current

Information By: Université de Sherbrooke

Dates:
Date Received: January 22, 2017
Date Started: June 2011
Date Completion: December 2017
Last Updated: February 20, 2017
Last Verified: February 2017