Clinical Trial: Effects of Lovaza on High Density Lipoprotein (HDL) Composition and Function in Hypertriglyceridemia

Study Status: Withdrawn
Recruit Status: Withdrawn
Study Type: Interventional

Official Title: Effects of Lovaza Monotherapy vs. Placebo on Composition and Function of HDL and Other Lipoproteins, and on Other Lipid-Related Parameters

Brief Summary:

Study hypothesis: Lovaza (purified prescription fish oil) is likely to help HDL (the "good cholesterol") work better.

Study summary: We are testing effects of Lovaza versus placebo, on various aspects of HDL and other lipoproteins, in patients with high triglyceride levels.

Study funding: This study is being funded by an investigator-initiated research grant from Glaxo Smith Kline.


Detailed Summary:
Sponsor: University of Utah

Current Primary Outcome: HDL Composition [ Time Frame: 12 weeks ]

HDL composition (protein and lipid) by size (gel filtration column)


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • HDL cholesterol composition by density subfraction [ Time Frame: 12 weeks ]
    HDL composition by density gradient ultracentrifugation
  • Safety [ Time Frame: 12 weeks ]
    Transaminases and glucose levels


Original Secondary Outcome: Same as current

Information By: University of Utah

Dates:
Date Received: May 17, 2010
Date Started: August 2010
Date Completion: October 2012
Last Updated: February 4, 2016
Last Verified: July 2011