Clinical Trial: Predictive Value of Flow MRI in Normal Pressure Hydrocephalus Surgery

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Predictive Value of Flow MRI in Normal Pressure Hydrocephalus Surgery

Brief Summary:

The idea is to assess the predictive value of flow magnetic resonance imaging (flow MRI) for patient suffering normal pressure hydrocephalus (NPH) planned for surgery. By now, the depletive lumbar puncture is the best test assessing the efficacy of a forthcoming surgery. The idea is to demonstrate that flow MRI can be as effective as lumbar puncture in term of predictive value of surgery response.

In that way, cerebrospinal fluid (CSF) dynamics are evaluated by a single non invasive examination. CSF flow is measured at the Sylvius' aqueduct, cervical, arachnoid space and 4th ventricle levels.


Detailed Summary:
Sponsor: Centre Hospitalier Universitaire, Amiens

Current Primary Outcome: CSF stroke volume [ Time Frame: Day 1 ]

Measurement of CSF stroke volume via flow MRI at the Sylvius' aqueduct level


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Hakim's triad evaluation [ Time Frame: Day 1 ]
    Assessment of the signs of normal pressure hydrocephalus
  • Hakim's triad evaluation [ Time Frame: Day 90 ]
    Assessment of the signs of normal pressure hydrocephalus (follow-up)
  • Hakim's triad evaluation [ Time Frame: Day 365 ]
    Assessment of the signs of normal pressure hydrocephalus (follow-up)
  • Neuropsychological test [ Time Frame: Day 1 ]
    classical neuropsychological assessment (including mini mental status evaluation)
  • Neuropsychological test [ Time Frame: Day 90 ]
    classical neuropsychological assessment (including mini mental status evaluation) (follow up)
  • Neuropsychological test [ Time Frame: Day 365 ]
    classical neuropsychological assessment (including mini mental status evaluation) (follow up)
  • CSF stroke volume [ Time Frame: Day 60 ]
    Measurement of CSF stroke volume by flow MRI at the Sylvius' aqueduct level (follow-up)
  • CSF stroke volume [ Time Frame: Day 365 ]
    Measurement of CSF stroke volume by flow MRI at the Sylvius' aqueduct level (follow-up)


Original Secondary Outcome: Same as current

Information By: Centre Hospitalier Universitaire, Amiens

Dates:
Date Received: March 19, 2013
Date Started: March 2006
Date Completion:
Last Updated: March 19, 2013
Last Verified: March 2013