Clinical Trial: Comparative Study of Different I-131 Doses in Graves' Disease

Study Status: Not yet recruiting
Recruit Status: Unknown status
Study Type: Interventional

Official Title: The Effect of Different Calculated Doses of I-131 in Treatment of Patients With Grave's Disease

Brief Summary: Radioactive iodine (RAI) administration is an effective and completely established treatment modality in hyperthyroidism including Graves' disease. Despite the long experience with radioiodine for hyperthyroidism, controversy remains regarding the optimal dose of iodine that is required to achieve long-term euthyroidism. The fixed activity administration method does not optimize the therapy, giving often too high or too low radiation to the gland, but the optimal dose per gram of thyroid mass in calculated activity administration method is also under much debates. This prospective study has been designed in order to compare the effect of different calculated doses of radioiodine on Graves' disease treatment outcome.

Detailed Summary:
Sponsor: Mashhad University of Medical Sciences

Current Primary Outcome: change of thyroid related hormones blood level from baseline at 1,3,6 and 12 month [ Time Frame: 1,3,6,12 month ]

Original Primary Outcome: Same as current

Current Secondary Outcome: Rate of hypothyroidism status at 1, 3,6 and 12 month post RAI therapy [ Time Frame: 1,3,6,12 month ]

Original Secondary Outcome: Same as current

Information By: Mashhad University of Medical Sciences

Dates:
Date Received: April 12, 2014
Date Started: May 2013
Date Completion: December 2016
Last Updated: April 14, 2014
Last Verified: April 2014