Clinical Trial: Effect of H. Pylori Eradication on the Reversibility of Atrophic Gastritis and Intestinal Metaplasia in Korean Patients
Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational
Official Title: Effect of Helicobacter Pylori Eradication on the Reversibility of Atrophic Gastritis and Intestinal Metaplasia in Korean Patients.
Brief Summary: Helicobacter pylori (H. pylori) infection has been associated with a development of atrophic gastritis and intestinal metaplasia. H. pylori related atrophic gastritis and intestinal metaplasia have been regarded as pre-malignant lesion. However, the role of H. pylori eradication treatment in the reversibility of atrophic gastritis and intestinal metaplasia has not been clearly defined. The aim of the present study was to investigate the relationship between H. pylori eradication and the reversibility of atrophic gastritis and intestinal metaplasia in Korean patients.
Detailed Summary: It is a prospective, case-control study to compare the status of atrophic gastritis and intestinal metaplasia from the patients who undergo H. pylori eradication treatment or not. After enrollment, each patient will be receive annual surveillance upper gastrointestinal endoscopy. The present investigators will monitor the status of atrophic gastritis and intestinal metaplasia annually and finally compare the reversibility of them.
Sponsor: Seoul National University Bundang Hospital
Current Primary Outcome: The improvement of Atrophic Gastritis and Intestinal metaplasia score [ Time Frame: per 1 year ]
The improvement of Atrophic Gastritis and Intestinal metaplasia was defined as improvement of score compared with baseline.
The histological features of the gastric mucosa were recorded using updated Sydney system scores, that is, 0 = none, 1 = mild, 2 = moderate, and 3 = marked.(Am J Surg Pathol 1996;20:1161-81.) Outcome measure will be done annually (per 1 year), final follow-up is 2019
Original Primary Outcome: Same as current
Current Secondary Outcome:
Original Secondary Outcome:
Information By: Seoul National University Bundang Hospital
Dates:
Date Received: February 14, 2016
Date Started: February 2006
Date Completion: February 2019
Last Updated: February 20, 2016
Last Verified: February 2016
