Clinical Trial: Impact of Emotional Mimicry and Oxytocin on Frontotemporal Dementia
Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional
Official Title: Impact of Emotional Mimicry and Oxytocin on Frontotemporal Dementia
Brief Summary: This study will evaluate the effects on emotions and neural activity of a one time dose of intranasal oxytocin vs. placebo in patients with FTD and healthy controls.
Detailed Summary: Frontotemporal dementia (FTD) and Pick's disease cause changes in personality, behaviour, and emotional responses. The usual treatments for Frontotemporal dementia focus on reducing agitation and aggressive behaviours. However, these drugs do not help all patients who experience blunting of emotion and loss of empathy. This study will evaluate the effects on emotions and neural activity of a one time dose of intranasal oxytocin vs. placebo in patients with FTD and healthy controls.
Sponsor: Lawson Health Research Institute
Current Primary Outcome: Functional magnetic resonance imaging (fMRI) BOLD signal [ Time Frame: 2 weeks ]
Original Primary Outcome: Same as current
Current Secondary Outcome: Cognitive and Emotional Task performance [ Time Frame: 2 weeks ]
Original Secondary Outcome: Same as current
Information By: Lawson Health Research Institute
Dates:
Date Received: September 3, 2013
Date Started: September 2013
Date Completion: March 2018
Last Updated: March 9, 2017
Last Verified: March 2017