Clinical Trial: Human Immune Responses to The Yellow Fever Virus Vaccine

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional

Official Title: Human Immune Responses to Yellow Fever Vaccination

Brief Summary:

The objective of this study is to study immune memory generated against the yellow fever vaccine (YFV) in participants who recently received the YFV vaccine. Volunteers who are planning to travel to yellow fever endemic areas will be recruited into this study. Volunteers will receive the yellow fever vaccine at the Hope Clinic of Emory University or at their private health care provider's office. Blood tests will be drawn before the vaccination and at upto 8 visits following vaccination. A volunteers's study participation may will last as short as 1 month or as long as one year depending on the immune responses.

We plan to compare the immune responses in younger people (18 to 45 years) to that of older people (55 or above).

Detailed Summary:
Sponsor: Emory University

Current Primary Outcome: 1. Isolation and characterization of yellow fever vaccine (YFV-17D) specific adaptive immune responses: characterize the magnitude and quality of YFV specific T cell responses, antibody secreting cells and memory B cells. [ Time Frame: Upto 12 months after vaccination ]

Original Primary Outcome: Isolation and characterization of yellow fever vaccine specific CD8 T cells during effector and memory phases [ Time Frame: Upto 3 months after vaccination ]

Current Secondary Outcome: Determine the signatures of innate immune responses: cytokines, chemokines, dendritic cells and microarray analyses on peripheral blood mononuclear cells [ Time Frame: Upto 12 months after vaccination ]

Original Secondary Outcome:

Information By: Emory University

Dates:
Date Received: May 19, 2008
Date Started: May 2008
Date Completion: December 2020
Last Updated: August 16, 2016
Last Verified: August 2016