Clinical Trial: Maternal Serum Vascular Endothelial Growth Factor in Pregnant Women With Foetal Growth Restriction
Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational
Official Title: Evaluation of Maternal Serum VEGF in Pregnant Women With Foetal Growth Restriction
Brief Summary: In this study we explore To explore the role of maternal serum vascular endothelial growth factor (VEGF) in pregnancies complicated by foetal growth restriction.
Detailed Summary: Small-for-gestational age (SGA) is defined as an estimated foetal weight (EFW) or abdominal circumference (AC) less than the 10th centileand severe SGA as an EFW or AC less than the 3rd centile. Foetal Growth Restriction refers to failure of the foetus to achieve its predetermined growth potential for various reasons.Foetus with foetal growth restriction (FGR) greatly contributes to perinatal mortality and short- and long-term morbidity. There is a 3-10 fold increase in perinatal mortality in pregnancies complicated by this FGR .The incidence of FGR in newborns ranges between 3 and 7% of the total population .FGR is thought to stem from placental hypoxia-induced vasoconstriction of the fetoplacental vessels, leading to placental hypoperfusion and thus fetal undernutrition. However, the effects of hypoxia on the fetoplacental vessels have been surprisingly little studied.Vascular endothelial growth factor (VEGF) is one of the factors that take part in placental angiogenesis. It is highly expressed during embryonic and foetal development..Angiogenesis involves the branching of new microvessles from pre-existing larger blood vessels.Angiogenesis plays a role in the development of the villous vasculature and the formation of terminal villi in human placenta. IUGR occurs as a result of the failure of elongation, branching and dilatation of the capillary loops and of terminal villous formation.
Sponsor: Beni-Suef University
Current Primary Outcome: Obstetric ultrasound [ Time Frame: from 28 weeks gestation to 36 weeks gestation ]
Original Primary Outcome: Same as current
Current Secondary Outcome: Serum Vascular Endothelial growth factor [ Time Frame: 3 months until delivery ]
Original Secondary Outcome: Same as current
Information By: Beni-Suef University
Dates:
Date Received: September 17, 2014
Date Started: September 2014
Date Completion: August 2017
Last Updated: May 13, 2017
Last Verified: May 2017