Clinical Trial: Comparison of the Pharmacodynamics of Imipenem in Patients With Febrile Neutropenia

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Comparison of the Pharmacodynamics of Imipenem in Patients With Febrile Neutropenia Following Administration by 4-hour Infusion and Bolus Injection.

Brief Summary:

This is prospective and randomized study to compare the pharmacodynamics (t>MIC) of 0.5 g every 6 h of imipenem in twelve patients with febrile neutropenia following administration by a 4 h infusion or bolus injection.

Concentration of imipenem in plasma will be measured by HPLC method and simulated in Monte Carlo technique (Computer model) to get PK/PD index (40%T>MIC) and reported to %PTA (Probability Target Attainment) and %CFR (Cumulative Faction Response.


Detailed Summary:
Sponsor: Prince of Songkla University

Current Primary Outcome: Concentration of imipenem in plasma [ Time Frame: 6 hours profile after 8th dose of imipenem ]

Concentration of imipenem in plasma will be determined by HPLC method and simulated in Monte Carlo technique (Computer model) to get PK/PD index (40%T>MIC) and reported to % PTA (Probability Target Attainment) and %CFR (Cumulative Faction Response).


Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Prince of Songkla University

Dates:
Date Received: August 8, 2014
Date Started: February 2011
Date Completion:
Last Updated: August 8, 2014
Last Verified: August 2014