Clinical Trial: Evaluation of Optimal Time of Methimazole Discontinuation Before Radio-iodine Therapy in Hyperthyroid Grave's Patients

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title:

Brief Summary:

Iodine therapy is the best treatment for graves disease.Most patients receive methimozale prior to radio-iodine treatment. This may decrease treatment response to iodine therapy.

Some physicians advice to discontinue methimazole 3 days before radioiodine therapy and others prefer longer off - methimazole period which bothers most patients. This study aimed to evaluate optimum time for methimazole discontinuation in graves disease.


Detailed Summary:
Sponsor: Mashhad University of Medical Sciences

Current Primary Outcome: thyroid function tests over one year after radioiodine therapy [ Time Frame: months 1 , 3 ,6,9,12 ]

thyroid function test may change over one year . In order to consider the patients as cured ,thyroid function tests should reveal hypothyroidism or euthyroidism . In order to rule out temporary hypothyroidism the tests should be repeated after 6 months of radioiodine therapy.


Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Mashhad University of Medical Sciences

Dates:
Date Received: March 1, 2012
Date Started: February 2010
Date Completion:
Last Updated: March 20, 2012
Last Verified: March 2012