Clinical Trial: Topiramate as an Adjunct to Amantadine in the Treatment of Dyskinesia in Parkinson's Disease
Study Status: Terminated
Recruit Status: Terminated
Study Type: Interventional
Official Title: Topiramate as an Adjunct to Amantadine in the Treatment of Dyskinesia in Parkinson's Disease
Brief Summary: The study will involve an eighteen-week, double-blind, placebo-controlled parallel designed comparison between add-on topiramate and add-on placebo to stable treatment with amatadine in the treatment of PD patients who continue to have dyskinesia on amantadine.
Detailed Summary:
Sponsor: Rush University Medical Center
Current Primary Outcome: The Unified Dyskinesia Rating Scale (UDysRS) [ Time Frame: Baseline, Week 10 and week 14 performed by blinded rater ]
Original Primary Outcome: Same as current
Current Secondary Outcome: Clinical Global Impression - Change score [ Time Frame: Assessed at Week 10 and 14 by blinded treating physician and subject ]
Original Secondary Outcome: Same as current
Information By: Rush University Medical Center
Dates:
Date Received: February 7, 2013
Date Started: March 2013
Date Completion:
Last Updated: November 4, 2016
Last Verified: November 2016