Clinical Trial: Trial Assessing the Efficacy of a Short Course of Intravenous Antibiotic Followed by Oral Antibiotic in Uncomplicated Acute Diverticulitis
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: Prospective Randomized Clinical Trial Assessing the Efficacy of a Short Course of Intravenous Amoxicillin Plus Clavulanic Acid Followed by Oral Antibiotic in Patients With Uncomplicated Acute
Brief Summary: Medical treatment of uncomplicated acute diverticulitis is not standardized and there is an enormous diversity in clinical practice. The investigators' aim was to demonstrate that uncomplicated diverticulitis can be managed with oral amoxicillin plus clavulanic acid with a short hospital admission.
Detailed Summary: A prospective randomized trial was established to compare patients with uncomplicated diverticulitis who received oral antibiotic after a short course of intravenous antibiotic, with those who received intravenous antibiotic for a longer period. We included 50 patients, 25 in each group. Patients in group 1 begun oral antibiotic as soon as they improved and were discharged the day after. Patients in group 2 received intravenous antibiotic for 7 days. Both groups received oral antibiotic at discharge. The endpoint of the study was "failure of treatment" which was defined as the impossibility of discharging on the expected day, emergency admission or hospital readmission.
Sponsor: Consorci Sanitari de Terrassa
Current Primary Outcome: failure of treatment [ Time Frame: the 4th day (group 1) or the 8th day (group 2) ]
Original Primary Outcome: Same as current
Current Secondary Outcome: emergency admission or hospital readmission for reasons related to the previous diverticulitis [ Time Frame: 30 days after discharge ]
Original Secondary Outcome: Same as current
Information By: Consorci Sanitari de Terrassa
Dates:
Date Received: June 8, 2009
Date Started: December 2005
Date Completion:
Last Updated: June 8, 2009
Last Verified: June 2009