Clinical Trial: Reduction of Dentine Hypersensitivity Using 8% Arginine Based Toothpaste and 8% Strontium Acetate Based Toothpaste (DH)

Study Status: Not yet recruiting
Recruit Status: Not yet recruiting
Study Type: Interventional

Official Title: Reduction of Dentine Hypersensitivity Using 8% Arginine Based Toothpaste and 8% Strontium Acetate Based Toothpaste: Randomized Controlled Clinical Trial

Brief Summary: This is a randomized, triple-blind, placebo-controlled study. 51 subjects with a confirmed diagnosis of dentin hypersensitivity were randomized to one of three treatments: Arginine based toothpaste, strontium acetate based toothpaste , or placebo. Treatment will be done at baseline then patients will use the toothpaste at home twice per day by using soft bristled tooth brush and the given dentifrice using modified stillmans method as explained by examiner. Standard test stimuli is calibrated short blast of air syringe, will be applied to sensitive dentin surfaces. Subjects recorded the intensity of sensitivity in response to stimulus on a visual analog scale at baseline, and after 1 week, 2 weeks and 3 months.

Detailed Summary:

  • Study setting This study will be carried out on adult patients attending to the operative clinic in The Faculty of Oral and Dental Medicine, Cairo University, Egypt. The procedures will be carried out by postgraduate student esraa abdel ghaffar ahmed ali [B.D.S. 2012 from Misr International University] without an assistant.

  • Eligibility criteria

    • Inclusion criteria Normal adults will be recruited in this study, all the volunteers participated in this experiment will be healthy looking with free medical history.

Subjects aged between 18-35 years At least three sensitive teeth (buccal /facial) aspect with recession , abrasion, erosion with a score of >3 on verbal rating scale, ranging from 0-3= no pain/mild pain, 4-6= moderate pain, and 7- 10= severe pain. Subjects were required to be available for the duration of the study, and to sign an informed consent form

-Exclusion criteria Subjects with a history of allergy to any of the drugs or chemicals used in the study.

Any removable appliance (RPD or orthodontic retainer). Ongoing orthodontic treatment with fixed appliances.

Presence of any large or defective restorations, cracked enamel or caries on the hypersensitive tooth.

Pregnancy and lactating mothers. Dental pathology causing pain similar to dentin hypersensitivity. Patients with any systemic problem or mental or physical disability

-Grouping of participants: Participants will be tested in this study having at le
Sponsor: Cairo University

Current Primary Outcome: reduction of dentin hypersensitivity [ Time Frame: 3 months ]

Subjects recorded the intensity of sensitivity in response to stimulus on a visual analog scale


Original Primary Outcome: reduction of dentin hypersenstivity [ Time Frame: 3 months ]

Subjects recorded the intensity of sensitivity in response to stimulus on a visual analog scale


Current Secondary Outcome:

Original Secondary Outcome:

Information By: Cairo University

Dates:
Date Received: February 19, 2017
Date Started: March 3, 2017
Date Completion: November 30, 2018
Last Updated: February 22, 2017
Last Verified: February 2017