Clinical Trial: Human Pulpal Response After Pulp Capping With Four Different Agents

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Comparison of Human Pulpal Response After Pulpal Exposure to Common Treatments and Single-visit MTA

Brief Summary: Application of four different pulp capping methods on human sound premolars after intentional exposure of the buccal pulp horn through a class one occlusal cavity.

Detailed Summary: The purpose of this clinical trial is to compare the effect of different direct pulp capping methods on human pulpal response in the terms of inflammation & dentinal bridge formation. Methods: Eight patients providing 32 sound first premolars are selected. As recommended by ISO / TC 7405 pulpal exposure will be performed through a class I cavity. Four groups of eight specimens each will be defined according to the pulp capping method. Group A, will receive chemical set calcium hydroxide (Dycal). Group B, will receive mineral Trioxide Aggregate (MTA) according to manufacturer's instruction. Group C, will receive MTA and after its primary setting, within 15 minutes, the cavity is restored in the same appointment. Group D, will receive Multical as a direct pulp capping agent. Specimens will be assessed in the terms of dentinal bridge formation, its appearance compared to natural dentin, its thickness and inflammatory pulpal response. The last item will be scored 0-3 in which 0 corresponds to none, 1 to minimal, 2 to moderate and 3 to severe inflammation. In case of an abscess or true tissue necrosis, a score of 4 will be given as recommended by ISO / TC 7405.
Sponsor: Islamic Azad University, Tehran

Current Primary Outcome: histologic findings - inflammation of the pulp [ Time Frame: 6weeks ]

According to histological evaluation and ISO/DIS7405, the investigators gave to non inflamed cases no points, mild cases 1 point, moderate cases 2 points, severe cases 3 points and necrosis 4 points.


Original Primary Outcome: Same as current

Current Secondary Outcome: histologic findings - formation of the dentinal bridge [ Time Frame: 6 weeks ]

The specimens will be evaluated in the terms of dentinal bridge formation and its resemblence to natural dentin and also the thickness of the bridge.


Original Secondary Outcome: Same as current

Information By: Islamic Azad University, Tehran

Dates:
Date Received: November 4, 2011
Date Started: June 2010
Date Completion:
Last Updated: November 8, 2011
Last Verified: November 2011