Clinical Trial: Pathogenic Species and Genotypes of Bacterial Diversity in Relation to the Severity of Dental Caries

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational

Official Title: Prevalence and Identification of Pathogenic Species and Genotypes of Bacterial Diversity in Relation to the Severity of Dental Caries

Brief Summary: The primary objective of this study is to estimate the distribution of pathogenic species and genotypes of bacterial diversity in 7 stages ICDAS (International Caries Detection and Assessment System) corresponding to the severity of dental caries among patients aged 3-45 years consulting in the Dentistry Departments of the Nîmes University Hospital and the Montpellier University Hospital.

Detailed Summary:

Secondary objectives include:

  • Compare the distribution of bacterial species in relation to stages of severity of caries
  • Compare the results from plaque with those of saliva samples.

Sponsor: Centre Hospitalier Universitaire de Nīmes

Current Primary Outcome:

  • Bacterial profile [ Time Frame: Baseline (day 0) ]
    Bacterial profiles will be constructed using saliva and plaque samples.
  • ICDAS assessment [ Time Frame: Baseline (day 0) ]
    Dental caries will be assessed using the ICDAS (International Caries Detection and Assessment System) system


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Studies were stopped during high school? yes/no [ Time Frame: baseline (Day 0) ]
  • Does the patient have at least five fillings? yes/no [ Time Frame: Baseline (day 0) ]
  • Does the patient have at least one filling and one missing tooth on the anterior sector following the carious lesion? yes/no [ Time Frame: baseline (day 0) ]
  • Within the last 12 months, the patient has had dental care or tooth removal following the carious lesion? yes/no [ Time Frame: baseline (day 0) ]
  • Yesterday, did the patient eat at least three snacks (or sugary or carbonated drinks) between meals? yes/no [ Time Frame: Baseline (day 0) ]
  • Yesterday, did the patient brush his/her teeth fewer than 2 times? yes/no [ Time Frame: baseline (day 0) ]
  • The patient has at least one carious lesion restricted to the enamel? yes/no [ Time Frame: baseline (day 0) ]
  • The patient has at least one carious lesion restricted to the enamel on an anterior tooth or involving the smooth surface on a posterior tooth (yes/no) [ Time Frame: baseline (day 0) ]
  • The patient has at least one carious lesion attacking the dentin or pulp. yes/no [ Time Frame: baseline (day 0) ]
  • The patient has at least one carious lesion reaching dentin or pulp on an anterior tooth or on the smooth surface of a posterior tooth (yes/no) [ Time Frame: baseline (day 0) ]


Original Secondary Outcome: Same as current

Information By: Centre Hospitalier Universitaire de Nīmes

Dates:
Date Received: February 4, 2014
Date Started: March 15, 2016
Date Completion: March 2017
Last Updated: January 31, 2017
Last Verified: March 2016