Clinical Trial: A Study to Evaluate the Potential of Mesenchymal Stromal Cells to Treat Obliterative Bronchiolitis After Lung Transplantation
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: A Study to Evaluate the Potential of Mesenchymal Stromal Cells to Treat Obliterative Bronchiolitis After Lung Transplantation
Brief Summary: The primary aim of this study is to establish the safety of infusions of Mesenchymal Stromal Cells (MSC) from related or unrelated Human Leukocyte Antigen (HLA) identical or HLA mismatched donors in the management of bronchiolitis obliterans syndrome after lung transplantation.
Detailed Summary:
Sponsor: The Prince Charles Hospital
Current Primary Outcome: To establish the safety of infusions of MSC from related or unrelated HLA identical or HLA mismatched donors in the management of bronchiolitis obliterans syndrome after lung transplantation. [ Time Frame: 12 months ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
- To document changes in lung function and 6 minute walk distance (6MWD) following infusion of MSC [ Time Frame: 12 months ]
- To document survival post MSC infusion [ Time Frame: 12 months ]
Original Secondary Outcome: Same as current
Information By: The Prince Charles Hospital
Dates:
Date Received: June 25, 2010
Date Started: February 2010
Date Completion:
Last Updated: October 10, 2016
Last Verified: October 2016
