Clinical Trial: Imaging Cardiac Electrical Remodeling With Electrocardiogram Imaging (ECGI)

Study Status: Completed
Recruit Status: Unknown status
Study Type: Observational

Official Title: Imaging Cardiac Electrical Remodeling With ECGI

Brief Summary: A consequence of chronic RV pacing is a process of electrical remodeling that alters myocardial repolarization to reflect the altered depolarization induced by the RV lead. When RV pacing is discontinued, the altered repolarization persists for several weeks. This phenomena is traditionally described as "T-wave memory" based upon the 12-lead ECG appearance of inverted T-Waves. The investigators are using the ECGI technique to produce three dimensional electroanatomical images of this phenomena in patients with dual chamber pacemakers. Echocardiography will also be used to image the mechanical effects of RV pacing and T-wave memory. The images will show the spatial distribution of altered repolarization and allow us to correlate any mechanical consequences of this phenomena that may exist.

Detailed Summary:
Sponsor: Washington University School of Medicine

Current Primary Outcome: ECGI Image [ Time Frame: 1 month after RV pacing ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Washington University School of Medicine

Dates:
Date Received: November 3, 2008
Date Started: November 2007
Date Completion: November 2009
Last Updated: November 4, 2008
Last Verified: November 2008