Clinical Trial: Origin of Premature Atrial Beats Induced by Simulated Obstructive Sleep Apnea

Study Status: Terminated
Recruit Status: Terminated
Study Type: Interventional

Official Title: Electroanatomic Origin of Premature Atrial Beats in Patients With Paroxysmal Atrial Fibrillation Induced by Intra-thoracic Pressure Swings Simulating Obstructive Sleep Apn

Brief Summary: There is accumulating evidence for obstructive sleep apnea (OSA) as an independent risk factor for paroxysmal atrial fibrillation and for high recurrence rates of atrial fibrillation after ablation therapy. We have previously shown that simulated OSA triggers premature atrial beats (PABs) by acute changes in intra-thoracic pressure. Most episodes of atrial fibrillation are initiated by PABs. However, the origin of PABs induced by intra-thoracic pressure swings is unknown. This study investigates the origin of premature atrial beats induced by intra-thoracic pressure changes that simulate obstructive sleep apnea in patients with atrial fibrillation.

Detailed Summary:
Sponsor: University of Zurich

Current Primary Outcome: Electroanatomical origin of premature atrial beats [ Time Frame: Participants will be followed for the duration of pulmonary vein isolation, an expected average of 3 hours ]

(Loop-)Catheter-based origin detection in patients with apnea-hypopnea index > 5/h in home sleep study and documented premature atrial beats during three time points: baseline (normal breathing), inspiration through a threshold load device, and the Mueller Manoeuvre (MM). Origins will be quantitatively marked at a left atrial map.


Original Primary Outcome: Same as current

Current Secondary Outcome: Catheter-based pressure in the left atrium and pulmonary veins during intra-thoracic pressure changes [ Time Frame: Participants will be followed for the duration of pulmonary vein isolation, an expected average of 3 hours ]

Catheter-based left atrial pressure measurement in patients with apnea-hypopnea index > 5/h in home sleep study and documented premature atrial beats during three time points: baseline (normal breathing), inspiration through a threshold load device, and the Mueller Manoeuvre. Changes in left atrial pressure will be recorded in cmH2O.


Original Secondary Outcome: Same as current

Information By: University of Zurich

Dates:
Date Received: October 14, 2014
Date Started: September 2014
Date Completion:
Last Updated: October 24, 2016
Last Verified: October 2016