Clinical Trial: Study of Airway Inflammation in Relation to Exercise in Elite Athletes

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Study of Airway Inflammation in Relation to Exercise in Elite Athletes

Brief Summary: High school elite training programs are today more and more under development in several 'elite sport schools' in Belgium, in order to select and train future elite athletes already at young age. Little is known about the effects of sustained training on the potential development of asthma in adolescents during lung growth. It would be of great importance to be able to select the individuals at risk to develop exercise-induced asthma, already at the start of their enrollment in the 'elite sport school. This would allow physicians to follow their lung function parameters very closely and regularly; and, if necessary, start treatment early after the first signs of exercise-induced asthma.

Detailed Summary:

Competitive swimmers, competitive indoor athletes and control individuals performing sports at a recreational level will be recruited for the study.

They will perform a sport-specific training (swimmers and controls: swimming for 90 minutes, indoor athletes: basketball or volleyball for 90 minutes)

Baseline measurements:

  • Airway inflammation upper and lower airways will be assessed by collection of nasal fluid (nasal sponge will be inserted in nostril for 5 minutes), Fraction of exhaled Nitric Oxide measurement and sputum induction.
  • Upper and lower airway symptoms will be assessed by questionnaires (SinoNasal Outcome Measure-22, Visual Analogue Score, Asthma Symptom Score and Juniper Score)
  • Allergy will be assessed by skin prick test (on skin) and immunocap test (in blood, 1 tube of 10 ml).
  • Lung function and nasal patency will be measured by spirometry and Peak Nasal Inspiratory Flow measurement.
  • Exercise induced bronchoconstriction will be assessed by eucapnic voluntary hyperventilation test.

Measurements immediately after training:

  • Collection of nasal fluid
  • Assessment of upper airway symptoms (Visual Analogue Score)
  • Spirometry and Fraction of Exhaled Nitric Oxide measurement
  • Peak Nasal Inspiratory Flow measurement

Measurements 24 hours after training:

  • Sponsor: Universitaire Ziekenhuizen Leuven

    Current Primary Outcome: Measurement of airway inflammation [ Time Frame: Baseline, immediately after and 24 hours after sport-specific training ]

    Airway inflammation upper and lower airways will be assessed by collection of nasal fluid (nasal sponge will be inserted in nostril for 5 minutes), Fraction of exhaled Nitric Oxide measurement and sputum induction.


    Original Primary Outcome: Same as current

    Current Secondary Outcome: Measurement of exercise induced bronchoconstriction [ Time Frame: baseline ]

    Exercise induced bronchoconstriction will be assessed by eucapnic voluntary hyperventilation test.


    Original Secondary Outcome: Same as current

    Information By: Universitaire Ziekenhuizen Leuven

    Dates:
    Date Received: August 26, 2013
    Date Started: December 2011
    Date Completion:
    Last Updated: June 20, 2016
    Last Verified: June 2016