Clinical Trial: Role of Leukotrienes and Adenosine in Hyperpnea-induced Bronchospasm

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Role of Leukotrienes and Adenosine in Hyperpnea-induced Bronchospasm Determined by Dynamic Analysis of Exhaled Breath Condensate.

Brief Summary: This research is being conducted to help us better understand what causes exercise induced asthma. The investigators hypothesize that two types of chemicals, cysteinyl leukotrienes and adenosine, play an important role. The investigators will be measuring these chemicals in the exhaled breath of volunteers with exercise induced asthma as they undergo a test to mimic exercise induced asthma. The investigators will determine how the levels of these chemicals change in association with how lung function changes before, during and after an episode of exercise induced asthma.

Detailed Summary:
Sponsor: University of Vermont

Current Primary Outcome: Change in level of cystLTs and adenosine [ Time Frame: Before and after hyperpnea challenge ]

Original Primary Outcome: Same as current

Current Secondary Outcome: Change in pH of EBC and change in pulmonary function [ Time Frame: Before and after hyperpnea challenge ]

Original Secondary Outcome: Same as current

Information By: University of Vermont

Dates:
Date Received: July 2, 2008
Date Started: October 2007
Date Completion:
Last Updated: October 27, 2016
Last Verified: October 2016