Clinical Trial: A Prospective Study Measuring Exhaled Nitric Oxide in Exercise-Induced Asthma

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: A Prospective Study Measuring Exhaled Nitric Oxide in Exercise-Induced Asthma

Brief Summary:

Exercise induced bronchospasm (EIB), also known as exercise induced asthma (EIA) is a transient obstruction to airflow triggered by exertion.

It is now a well known identity, center of discussion in recent years, particularly in the athletes' world. It is more common in asthmatic individuals (regardless of severity of disease), but it is also seen in otherwise healthy subjects, leading to the general consensus that the pathophysiology is different than asthma.

The concentration of exhaled nitric oxide (FeNO) in various airway & respiratory disorders, particularly asthma, has been deeply studied. Its use for noninvasive monitoring of asthma control (reflecting airway eosinophilic inflammation) is being closely examined and put into clinical practice. FeNO is significantly elevated in asthma. Elevated FeNO levels have also been noted in patients hospitalized with a COPD exacerbation, acidosis, rhinitis, bronchiectasis, active pulmonary sarcoidosis, active fibrosing alveolitis, and acute lung allograft rejection. Decreased FeNO levels have been seen in patients with primary ciliary dyskinesia, cystic fibrosis, PiZZ phenotype-related alpha-1 antitrypsin deficiency, and pulmonary hypertension

Two studies have addressed the variations on FeNO after EIB and they had contradictory results. Scollo et al. found no change in FeNO in either healthy or asthmatic children after a 6-min of vigorous exertion in an exercise laboratory when they studied 24 asthmatic and 18 control children. Terada et al. reported, for 39 subjects, a decrease in FeNO in subjects with EIB and an increase in healthy controls.

It is well accepted that the pathophysiology of exercise induced bronchospasm it is not similar to that of asthma. Certainly the infla

Detailed Summary:
Sponsor: Melodi Pirzada MD

Current Primary Outcome: Variations in the fraction of exhaled nitric oxide in subjects with exercise induced asthma [ Time Frame: 1 year ]

The exhaled Nitric Oxide (FeNO) will be measured before the exercise test and at 5, 10 and 15 min after completion of the exercise to detect variations in the value


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Correlation between level of FeNO and reduction in FEV1 [ Time Frame: 1 year ]
    Variations in the FeNO will be compared to FEV1 changes to see if they correlate
  • Correlation between level of FeNO and severity of symptoms [ Time Frame: 1 year ]
    Variations in FeNO will be correlated with symptoms reported


Original Secondary Outcome: Same as current

Information By: Winthrop University Hospital

Dates:
Date Received: March 31, 2010
Date Started: April 2010
Date Completion:
Last Updated: June 13, 2013
Last Verified: June 2013