Clinical Trial: Ultrasound-guided Supraclavicular Brachial Plexus Block in Elderly

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Effects of Age on Minimum Effective Volume of Local Anesthetic for Ultrasound-guided Supraclavicular Brachial Plexus Block (US-SCB)

Brief Summary: The aim of this study is to determine the minimum effective volume of local anesthetic (50:50 mixture of 0.5% levobupivacaine and 2% lidocaine) required to produce an effective US-SCB for surgical anesthesia in 50% of patients and to calculate the effective volume required to produce an effective US-SCB in 95% of the patients (MEAV95) in elderly group (>65 years) and in middle aged group (<45years) of patients.

Detailed Summary: We believe that known data regarding the minimum anesthetic volume required for effective US-SCB from middle age population can not be applicable to the elderly population since our preliminary data, presented at Euroanesthesia meeting in Amsterdam, 2011, and published in abstract form in the European Journal of Anaesthesiology, showed that involutional changes of brachial plexus in elderly, assessed by measuring the cross-sectional area (CSA) of brachial plexus at the first rib, allowed a 35% reduction in local anesthetic volume for an effective US-SCB for surgical anesthesia in elderly patients in comparison with the younger patients.
Sponsor: Šarić, Jadranka Pavičić, M.D.

Current Primary Outcome: Ultrasound-guided Supraclavicular Brachial Plexus Block in Elderly [ Time Frame: A blinded Assistant assess sensory and motor blockade in a 5-min intervals up to 30 minutes ]

Determining the minimum effective volume of a 50:50 mixture of levobupivacaine 0.5% and lidocaine 2% for successful supraclavicular brachial plexus block for hand surgery in 50% of elderly patients (MEAV50) and to calculate the effective volume in 95% of the elderly patients (MEAV95) as compared with control group (middle aged patients).


Original Primary Outcome: Ultrasound-guided Supraclavicular Brachial Plexus Block in Elderly [ Time Frame: A blinded Assistant assess sensory and motor blockade in a 5-min intervals up to 30 minutes ]

Determining the minimum effective volume of a 50:50 mixture of levobupivacaine 0.5% and lidocaine 2% for successful supraclavicular brachial plexus block for hand surgery in 50% of elderly patients (MEAV50) and to calculate the effective volume in 95% of the elderly patients (MEAV95).


Current Secondary Outcome: Ultrasound-guided Supraclavicular Brachial Plexus Block in... [ Time Frame: A blinded Assistant assess onset (in a 5-min intervals up to 30 minutes after completion of US-SCB) ) and duration of sensory and motor blockade (in a 30-min intervals after the completion of surgery). ]

Sensory and motor block onset time and duration for each nerve (median, radial, ulnar and musculocutaneous) and for the group.


Original Secondary Outcome: Same as current

Information By: Šarić, Jadranka Pavičić, M.D.

Dates:
Date Received: November 4, 2011
Date Started: November 2011
Date Completion:
Last Updated: November 14, 2012
Last Verified: November 2012