Clinical Trial: Brain Biomarkers of Response to Treatment for Apraxia of Speech
Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional
Official Title: Brain Biomarkers of Response to Treatment for Apraxia of Speech
Brief Summary: The study will use MRI brain imaging to identify brain changes associated in stroke patients after they receive speech-language treatment for their speech difficulties.
Detailed Summary: The goals of the current study are to identify grey and white matter regions that are predictive of speech treatment response and measure neural plasticity in response to speech treatment, using state-of-the-art neuroimaging and statistical processing techniques in a group of well-characterized left hemisphere patients meeting strict inclusionary criteria. Specifically, the investigators will use voxel-based lesion symptom mapping to identify lesion sites most predictive of a positive response to speech treatment and advanced diffusion imaging techniques to map changes in the integrity of white matter tracts from pre- to post-treatment.
Sponsor: VA Office of Research and Development
Current Primary Outcome: Percent change in naming score for trained and untrained items [ Time Frame: 8 weeks ]
Original Primary Outcome: Same as current
Current Secondary Outcome: Change in fractional anisotropy [ Time Frame: 8 weeks ]
Original Secondary Outcome: Change in fractional anisotropy [ Time Frame: 8 weeks ]
Information By: VA Office of Research and Development
Dates:
Date Received: January 24, 2014
Date Started: March 1, 2014
Date Completion: March 2018
Last Updated: February 23, 2017
Last Verified: February 2017