Clinical Trial: Development of a Novel Transdiagnostic Intervention for Anhedonia

Study Status: Not yet recruiting
Recruit Status: Not yet recruiting
Study Type: Interventional

Official Title: Development of a Novel Transdiagnostic Intervention for Anhedonia

Brief Summary: The overall goal of this project is to develop a novel transdiagnostic treatment for anhedonia, called Behavioral Activation Treatment for Anhedonia (BATA), using ultra-high field functional neuroimaging. There is a critical need for a validated treatment that specifically targets anhedonia, and this project will evaluate the effects of this new treatment on anhedonia and will establish how this treatment impacts brain systems that mediate reward processing, clinical symptoms of anhedonia, functional outcomes, and behavioral indices of reward processing. This work will also identify brain targets by which future novel anhedonia treatment may be evaluated.

Detailed Summary:
Sponsor: University of North Carolina, Chapel Hill

Current Primary Outcome: Change from Baseline to Week 15 in Neural Activation [ Time Frame: Baseline, 15 weeks ]

Neural activation assessed by Functional Magnetic Resonance Imaging (fMRI) during Monetary Incentive Delay (MID) task


Original Primary Outcome: Same as current

Current Secondary Outcome: Change from Baseline to Week 15 in Snaith-Hamilton Pleasure Scale Score [ Time Frame: Baseline, 15 weeks ]

The Snaith-Hamilton Pleasure Scale (SHAPS), a well-validated 14-item questionnaire will be used to assess hedonic capacity. The sum of the 14 items scores ranges from 0 to 56. A higher score represents more anhedonic symptoms.


Original Secondary Outcome: Same as current

Information By: University of North Carolina, Chapel Hill

Dates:
Date Received: August 17, 2016
Date Started: December 2016
Date Completion: November 2021
Last Updated: August 17, 2016
Last Verified: August 2016