Clinical Trial: Genetics of Spina Bifida and Anencephaly

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational

Official Title: The Hereditary Basis of Neural Tube Defects

Brief Summary: The goal of this research study is to discover the genetic and environmental factors that contribute to the cause of neural tube defects such as spina bifida and anencephaly. Ultimately, this type of research may result in improved diagnosis, improved treatment and possibly prevention.

Detailed Summary:

Participation in the study is entirely voluntary.

Individuals who are currently pregnant and the pregnancy has been diagnosed with anencephaly or acrania quality to participate.

Participation involves:

  1. Completing a written consent form
  2. A phone conversation to collect family and medical information
  3. Collection of blood samples from both parents of the pregnancy
  4. Provide a fetal DNA sample (cord blood, fetal tissue or amniotic fluid)
  5. Review of medical records and ultrasound images

Sponsor: Duke University

Current Primary Outcome: genetic factors associated with neural tube defects [ Time Frame: end of the study ]

This study aims to discover genetic factors associated with neural tube defects such as anencephaly.


Original Primary Outcome:

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Duke University

Dates:
Date Received: March 9, 2008
Date Started: May 1993
Date Completion: May 2020
Last Updated: April 20, 2017
Last Verified: April 2017