Clinical Trial: Use of Hyaluronic Acid as a Therapeutic Strategy for Bone Repair in Human

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Use of Hyaluronic Acid as a Therapeutic Strategy for Bone Repair in Human: a Split-mouth Randomized Triple-blind Clinical Trial

Brief Summary: The aim of this study is to evaluate the effects of hyaluronic acid (HA) on bone healing in human dental sockets.

Detailed Summary:
Sponsor: Federal University of Minas Gerais

Current Primary Outcome:

• Percentage of bone formation [ Time Frame: 30 days after extraction and treatment application ]
  During the postoperative interval of 30 days, the patients underwent cone beam computed tomography (CBCT). Five central transverse scan images were captured from each socket. Using the KS300 software, the gray intensity was measured in each image and the results were expressed as mean percentage of bone formation
• Fractal dimension [ Time Frame: 30 days after extraction and treatment application ]
  During the postoperative interval of 30 days, the patients underwent cone beam computed tomography (CBCT). Five central transverse scan images were captured from each socket. The pattern of the alveolar trabecular bone was also evaluated through the fractal dimension in each image.
• Dimensional Alveolar changes [ Time Frame: 30 to 90 days after extraction and treatment application ]
  To determine whether treatment could prevent loss of buccolingual thickness, was compared bone loss of 90 to 30 days between the treated and control groups.
• Percentage of bone formation [ Time Frame: 90 days after extraction and treatment application ]
  During the postoperative interval of 90 days, the patients underwent cone beam computed tomography (CBCT). Five central transverse scan images were captured from each socket. Using the KS300 software, the gray intensity was measured in each image and the results were expressed as mean percentage of bone formation
• Fractal dimension [ Time Frame: 90 days after
  
  

  Original Primary Outcome: Same as current
  
  

  Current Secondary Outcome:
  
  

  Original Secondary Outcome:
  
  Information By: Federal University of Minas Gerais
  

  Dates:
  Date Received: March 8, 2016
  Date Started: July 2012
  Date Completion:
  Last Updated: March 15, 2016
  Last Verified: March 2016