Clinical Trial: Alcohol Challenge On Liver and Gut Measured by Liver Vein Catheterization. A Pathophysiological Intervention Trial
Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional
Official Title:
Brief Summary: To investigate the effects of acute alcohol challenge on the gut and liver axis.
Detailed Summary: To study the role of acute alcohol challenge on the intestine permeability and inflow of bacterial products to the liver in participants with alcoholic liver disease, non-alcoholic steatohepatitis and healthy controls.
Sponsor: Odense University Hospital
Current Primary Outcome: changes in concentrations of bacterial products in the liver vein [ Time Frame: Within 24 hours ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
- changes in concentrations of bacterial products in the peripheral vein system [ Time Frame: Within 24 hours ]
- changes in the gut microbiome [ Time Frame: Within 24 hours ]
- changes in the liver metabolome, transcriptome and proteome [ Time Frame: Within 24 hours ]
- changes in serum-ethanol, plasma-glucose and liver biomarkers in the liver vein compared to the peripheral vein system [ Time Frame: Within 24 hours ]
Original Secondary Outcome: Same as current
Information By: Odense University Hospital
Dates:
Date Received: January 11, 2017
Date Started: January 2017
Date Completion: December 2019
Last Updated: January 11, 2017
Last Verified: January 2017
