Clinical Trial: CT Indexes of Emphysema and Airways in Healthy Volunteers: Normal Values; Relations With Gender, Height and Weight

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: CT Indexes of Emphysema and Airways in Healthy Volunteers: Normal Values; Relations With Gender, Height and Weight

Brief Summary: Various indexes have been proposed to quantify both pulmonary emphysema and airways disease on chest CT scans. It is unknown whether these indexes should be consider in absolute values or as compared to predicted normal values. The purposes of the present study is thus : a) to measure these indexes at CT in healthy volunteers; b) to investigate their relations with gender, height and weight.

Detailed Summary:

87 healthy volunteers performed consecutively a low-dose chest CT scan and pulmonary function tests:

  1. On chest CT scans, indexes reflecting pulmonary emphysema and airways measurements have been computed by using dedicated softwares. Each of our three readers performed two reading sessions.

    Relative area of lung parenchyma with attenuation value less than -960 Hounsfield Units; luminal area and wall thickness in third and fourth generations airways were recorded.

  2. Pulmonary function tests were performed: vital capacity, forced vital capacity , functional residual capacity, total lung capacity, residual volume, forced expiratory volume in one second, and diffusion lung capacity for carbon monoxide were recorded (either in absolute values and percentage of predicted values).

CT indexes were compared with gender, height and weight.


Sponsor: Erasme University Hospital

Current Primary Outcome:

  • CT index - RA960 (%) [ Time Frame: 4 hours ]
    From acquired data, images were reconstructed using a soft algorithm. On these soft images, the relative area of lung parenchyma with attenuation value less than -960 Hounsfield Units was computed (expressed in %), as an index representative of pulmonary emphysema extent.
  • CT index - LA3rd (mm2) [ Time Frame: 4 hours ]
    From acquired data, images were reconstructed using a high resolution algorithm. On these high-resolution images, the airway lumen was measured in third generations of airways (expressed in mm2).
  • CT index - LA4th (mm2) [ Time Frame: 4 hours ]
    From acquired data, images were reconstructed using a high resolution algorithm. On these high-resolution images, the airway lumen was measured in fourth generations of airways (expressed in mm2).
  • CT index - WT3rd (mm) [ Time Frame: 4 hours ]
    From acquired data, images were reconstructed using a high resolution algorithm. On these high-resolution images, the airway wall was measured in third generations of airways (expressed in mm).
  • CT index - WT4th (mm) [ Time Frame: 4 hours ]
    From acquired data, images were reconstructed using a high resolution algorithm. On these high-resolution images, the airway wall was measured in fourth generations of airways (expressed in mm).


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Pulmonary function tests - VC (l) [ Time Frame: 4 hours ]
    Vital capacity was measured (expressed in l).
  • Pulmonary function tests - FVC (l) [ Time Frame: 4 hours ]
    Forced vital capacity was measured (expressed in l).
  • Pulmonary function tests - FRC (l) [ Time Frame: 4 hours ]
    Functional residual capacity capacity was measured (expressed in l).
  • Pulmonary function tests - TLC (l) [ Time Frame: 4 hours ]
    Total lung capacity was measured (expressed in l).
  • Pulmonary function tests - RV (l) [ Time Frame: 4 hours ]
    Residual volume was measured (expressed in l).
  • Pulmonary function tests - FEV1 (l) [ Time Frame: 4 hours ]
    Forced expiratory volume in one second was measured (expressed in l).
  • Pulmonary function tests - DLCO (ml/min/ mmHg) [ Time Frame: 4 hours ]
    Diffusion lung capacity for carbon monoxide was measured (expressed in ml/min/ mmHg)


Original Secondary Outcome: Same as current

Information By: Erasme University Hospital

Dates:
Date Received: October 30, 2015
Date Started: October 2010
Date Completion:
Last Updated: November 19, 2015
Last Verified: November 2015