Clinical Trial: Exercise Capacity and Recovery in Addison's Disease

Study Status: Recruiting
Recruit Status: Unknown status
Study Type: Interventional

Official Title: Effect of Hydrocortisone Stress Dose on Exercise Capacity and Post-exercise Recovery in Patients With Addison's Disease

Brief Summary: Exposure to stress alters the activity of the adrenomedullary, adrenocortical and sympathetic nervous system, depending on the type and intensity of the stressor. Physical exercise represents a stress condition influencing many systems in the body. Given a workload of at least 70-85% of Vo2max, exercise is a potent stimulus of the hypothalamic-pituitary-adrenal (HPA)-axis. The increased endogenous cortisol secretion results in important metabolic and cardiovascular effects to maintain cellular and organ homeostasis. Patients with Addison's disease are not able to meet the increased demand of adrenal steroids in case of physical exercise, which may result in an impaired exercise capacity and a prolonged post-exercise recovery. We hypothesize that a hydrocortisone stress dose increases exercise capacity and improves post-exercise recovery in patients with Addison's disease.

Detailed Summary:
Sponsor: UMC Utrecht

Current Primary Outcome: exercise capacity [ Time Frame: 140 minutes ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: UMC Utrecht

Dates:
Date Received: August 1, 2012
Date Started: January 2013
Date Completion: January 2014
Last Updated: August 2, 2012
Last Verified: August 2012