Clinical Trial: Laboratory Characteristics in Chronic Atrophic Acrodermatitis

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional

Official Title: Inflammatory Proteins,Gene Polymorphisms, and Transcriptome Profiles in Patients With Chronic Atrophic Acrodermatitis

Brief Summary: The main objective of this study is to characterize the inflammatory proteins, gene polymorphisms, and transcriptome profiles in patients with chronic atrophic dermatitis to gain better insight into pathogenesis of chronic infection with Borrelia burgdorferi sensu lato.

Detailed Summary:
Sponsor: University Medical Centre Ljubljana

Current Primary Outcome: inflammatory proteins in patients with chronic atrophic dermatitis [ Time Frame: up to 24 months ]

The inflammatory immune profiles will be assessed using Luminex to measure the expression of cytokines and chemokines representative of innate and adaptive TH1, TH2, TH17, and B cell responses.


Original Primary Outcome: Same as current

Current Secondary Outcome: clinical characteristics of patients with chronic atrophic dermatitis treated with doxycycline for 14 or 28 days [ Time Frame: at enrollment, at 2, 6 12 and 24 months follow-up ]

Original Secondary Outcome: Same as current

Information By: University Medical Centre Ljubljana

Dates:
Date Received: June 24, 2013
Date Started: July 2013
Date Completion:
Last Updated: May 11, 2016
Last Verified: May 2016