Clinical Trial: Effect of Peritoneal Lavage With Clindamycin-gentamicin Solution on Postoperative Colorectal Cancer Infection in Elective Surgery
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: Effect of Peritoneal Lavage With Clindamycin-gentamicin Solution on Infection in Elective Surgery
Brief Summary: Intrabdominal antibiotic irrigation will reduce wound and intrabdominal infection.
Detailed Summary: A prospective, randomized study was performed between January and December 2010. Patient inclusion criteria were a diagnosis of colorectal neoplasms and plans to undergo an elective curative surgery. Patients were divided into 2 groups: Group 1 (intra-abdominal irrigation with normal saline) and Group 2 (intraperitoneal irrigation with a solution of 240 mg gentamicin and 600 mg clindamycin). The occurrence of wound infections and intra-abdominal abscesses were investigated. Following the anastomosis, a microbiological sample of the peritoneal surface was obtained (sample 1). A second sample was collected following an irrigation with normal saline (sample 2). Finally, the peritoneal cavity was irrigated with a gentamicin-clindamycin solution and a third sample was obtained (sample 3).
Sponsor: Universidad Miguel Hernandez de Elche
Current Primary Outcome: Surgical site infection [ Time Frame: 30 days ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
Original Secondary Outcome:
Information By: Universidad Miguel Hernandez de Elche
Dates:
Date Received: June 20, 2011
Date Started: January 2010
Date Completion:
Last Updated: June 21, 2011
Last Verified: January 2010