Clinical Trial: Tadalafil and Acetazolamide Versus Acetazolamide in Acute Mountain Sickness Prevention

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Tadalafil and Acetazolamide Versus Acetazolamide in Acute Mountain Sickness Prevention

Brief Summary: To evaluate the additive value of tadalafil given together with Diamox (acetazolamide) in preventing acute mountain sickness in travelers to high altitude areas.

Detailed Summary:

A randomized controlled study comparing:

Tadalafil [20mg x1/day] and acetazolamide [125mg x2 day], versus Acetazolamide [125mg x2 day] alone, in trekkers to altitude > 3,000 m.

Sponsor: Sheba Medical Center

Current Primary Outcome: Results will be evaluated by using the Lake Louise AMS scoring system [ Time Frame: one month after travel ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Sheba Medical Center

Dates:
Date Received: November 3, 2008
Date Started: January 2006
Date Completion:
Last Updated: September 7, 2012
Last Verified: September 2012