Clinical Trial: Gabapentin to Reduce Postoperative Nausea and Vomiting

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Gabapentin Premedication to Reduce Postoperative Nausea and Vomiting in Surgical Patient Receiving Spinal Morphine

Brief Summary: The intrathecal administration of morphine is gaining popularity. It is easy to do and can reduce the pain after surgery up to 24 hours. However, it causes postoperative nausea and vomiting more than other methods providing postoperative analgesia. Patients suffering from these side effects have to spend a longer period of time recovering in the hospital with high cost of medical treatment.

Detailed Summary:

Objective: to study the efficacy of oral administrating of gabapentin 600 mg before surgery to reduce the postoperative nausea and vomiting in patients receiving intrathecal morphine.

Methods: Eighty patients undergoing orthopedic surgery and receiving intrathecal morphine will be randomized into 2 groups. The first group will receive oral gabapentin 600 mg and the second group will receive a placebo tablet. Both groups will receive a standard prophylactic medication for postoperative nausea and vomiting. The degrees of nausea and vomiting in both groups will be assessed over 24 hours postoperatively.


Sponsor: Khon Kaen University

Current Primary Outcome: Postoperative nausea and vomiting (grade 1-3) [ Time Frame: through study completion, an average of 24 hours ]

PONV grading: 0 = none; 1 = mild; 2 = moderate; 3 = severe


Original Primary Outcome: Postoperative nausea and vomiting [ Time Frame: through study completion, an average of 24 hours ]

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Khon Kaen University

Dates:
Date Received: October 25, 2016
Date Started: August 2016
Date Completion:
Last Updated: May 10, 2017
Last Verified: May 2017