Clinical Trial: Efficacy Study of Cognitive Intervention in Amnestic Mild Cognitive Impairment

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: A Multicenter, Randomized Trial to Assess Efficacy of Home-based and Group Cognitive Intervention Programs in Amnestic Mild Cognitive Impairment

Brief Summary:

  • There will be a significant difference in cognitive function between cognitive intervention group (group therapy) and a wait list control group.
  • There will be a significant difference in cognitive function between a home-based cognitive intervention group and a wait list control group.

Detailed Summary: The change of Modified ADAS-cog score from the baseline to post-intervention will be compared between the cognitive intervention group and wait list control group.
Sponsor: Inha University Hospital

Current Primary Outcome: Modified Alzheimer's Disease Assessment Scale-Cognitive subscale(ADAS-cog) [ Time Frame: postintervention, 12 weeks follow-up, and 24 weeks follow-up ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

  • story recall test [ Time Frame: postintervention, 12 weeks follow-up, and 24 weeks follow-up ]
  • Digit span forward and backward [ Time Frame: postintervention, 12 weeks follow-up, and 24 weeks follow-up ]
  • Word fluency test [ Time Frame: postintervention, 12 weeks follow-up, and 24 weeks follow-up ]
  • color-word stroop test [ Time Frame: postintervention, 12 weeks follow-up, and 24 weeks follow-up ]
  • Digit symbol test [ Time Frame: postintervention, 12 weeks follow-up, and 24 weeks follow-up ]
  • prospective memory test [ Time Frame: postintervention, 12 weeks follow-up, and 24 weeks follow-up ]
  • Mini-Mental State Examination [ Time Frame: postintervention, 12 weeks follow-up, and 24 weeks follow-up ]
  • CDR-SB [ Time Frame: postintervention, 12 weeks follow-up, and 24 weeks follow-up ]
  • K-AD8 [ Time Frame: postintervention, 12 weeks follow-up, and 24 weeks follow-up ]
  • PRMQ [ Time Frame: postintervention, 12 weeks follow-up, and 24 weeks follow-up ]
  • MMQ-Strategy [ Time Frame: postintervention, 12 weeks follow-up, and 24 weeks follow-up ]
  • QOL-AD [ Time Frame: postintervention, 12 weeks follow-up, and 24 weeks follow-up ]
  • Geriatric Depression Scale-short form [ Time Frame: postintervention, 12 weeks follow-up, and 24 weeks follow-up ]
  • Bayer ADL [ Time Frame: postintervention, 12 weeks follow-up, and 24 weeks follow-up ]
  • CGA-NPI [ Time Frame: postintervention, 12 weeks follow-up, and 24 weeks follow-up ]
  • Subjective cognitive assessment [ Time Frame: postintervention, 12 weeks follow-up, and 24 weeks follow-up ]


Original Secondary Outcome: Same as current

Information By: Inha University Hospital

Dates:
Date Received: May 20, 2011
Date Started: March 2011
Date Completion:
Last Updated: August 27, 2013
Last Verified: August 2013