Clinical Trial: Decadron as Adjuvant in Femoral Nerve Blocks in Knee Arthroscopy
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: Dexamethasone as an Adjuvant to Ropivacaine for Femoral Nerve Blocks in Children Undergoing Knee Arthroscopy
Brief Summary: If preservative-free dexamethasone 0.1 mg/kg (max dose 4 mg) is added to ropivacaine 0.5% 2 mg/kg (max dose 100 mg), then post-PACU opioid consumption will be reduced by 33%.
Detailed Summary:
Following informed consent, patients will be randomized to one (1) of three (3) arms. Group D patients will receive 2 mg/kg of 0.5% ropivacaine (max. dose 100 mg) with 0.1 mg/kg preservative-free dexamethasone (max. dose 4 mg) perineurally for their femoral block. Group D will also receive a gluteal intramuscular injection of saline of volume equivalent to 0.1 mg/kg preservative-free dexamethasone (max. volume 0.4 ml). Group R patients will receive 2 mg/kg of 0.5% ropivacaine (max. dose 100 mg) combined with a volume of saline equivalent to 0.1 mg/kg preservative-free dexamethasone (max. volume 0.4 ml) perineurally. Group R will also receive a gluteal intramuscular injection of saline of volume equivalent to 0.1 mg/kg preservative-free dexamethasone (max. volume 0.4 ml). Group M patients will receive 2 mg/kg of 0.5% ropivacaine (max. dose 100 mg) combined with a volume of saline equivalent to 0.1 mg/kg preservative-free dexamethasone (max. volume 0.4 ml) perineurally. Group M will also receive a gluteal intramuscular injection of 0.1 mg/kg preservative-free dexamethasone (max. dose 4 mg). The randomization will be blinded to the patient, surgery team, anesthesia team, recovery nurses, and clinical research nurses.
The remainder of the anesthetic care will remain the same per our usual routine for these cases. On arrival to the operating room:
- Standard American Society of Anesthesiologists (ASA) monitors will be placed on the patient (ECG, pulse oximetry, non-invasive BP, thermistor).
- A peripheral intravenous catheter will be placed while patient is inhaling 50% nitrous oxide.
- Intravenous induction will be accomplished with midazolam 2 mg, propofol 2-3 mg/kg.
- Once induction is complete, a
Sponsor: Nationwide Children's Hospital
Current Primary Outcome: Post-PACU opioid consumption [ Time Frame: 48 hours post-operatively ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
Original Secondary Outcome:
Information By: Nationwide Children's Hospital
Dates:
Date Received: October 22, 2013
Date Started: July 2014
Date Completion:
Last Updated: February 1, 2017
Last Verified: February 2017
