Clinical Trial: Effects of Conventional Dry Eye Treatments on the Ocular Surface Response to Low Humidity Environment in Patients With Keratoconjunctivitis Sicca

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Effects of Conventional Dry Eye Treatments on the Ocular Surface Response to Low Humidity Environment in Patients With Keratoconjunctivitis Sicca.

Brief Summary:

The purpose of this study is to evaluate whether, in people with dry eye syndrome, over the counter artificial tears and the prescription eye drop, dexamethasone, change or effect the eyes response to a low humidity environment.

It is known that irritation from dry eye can be improved by over the counter artificial tears because they wet and lubricate the eyes. The prescription eye drop, dexamethasone, can also improve eye irritation by decreasing the inflammation that develops in dry eye. Thus, the investigators hypothesize that the use of these conventional dry eye treatments will improve the eyes' response to a low humidity environment.


Detailed Summary:
Sponsor: Baylor College of Medicine

Current Primary Outcome: Changes in ocular surface measured by routine opthalmic dyes [ Time Frame: Two weeks after treatment and exposure to a low humidity environment ]

Subjects will be exposed to a low humidity environment at initial examination and then after two weeks of using artificial tears, and lastly after two weeks of using dexamethasone. The changes in the ocular surface will be measured after each exposure to a low humidity environment.


Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Baylor College of Medicine

Dates:
Date Received: February 21, 2013
Date Started: February 2013
Date Completion:
Last Updated: January 25, 2016
Last Verified: January 2016