Clinical Trial: Safety and Efficacity of Corneal Collagen Crosslinking in Infectious Keratitis (Bacterial and Fungal ): Randomized,Controlled, Prospective Study. (CXL)
Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional
Official Title: Safety and Efficacity of Corneal Collagen Crosslinking in Infectious Keratitis (Bacterial and Fungal ): Randomized,Controlled, Prospective Study.
Brief Summary: The corneal collagen cross linking is currently used in the treatment of keratoconus but this procedure has also a sterilizing non-specific effect on bacteria and fungus. So the corneal cross linking in association with the antibiotic treatment could result in a reduction of the duration of epithelial complete healing of the cornea.
Detailed Summary:
Sponsor: Nantes University Hospital
Current Primary Outcome: Duration of corneal complete epithelial healing in days. [ Time Frame: 3 months ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
- Size of the corneal scar [ Time Frame: 3months ]Size of the corneal scar at 3months expressed in % of the initial size of the corneal ulcer.
- Corneal thinning [ Time Frame: 3 months ]Corneal thinning estimated by Anterior segment optical coherence tomography at 3 months, expressed in microns.
- Gain of visual acuity [ Time Frame: 3 months ]Gain of visual acuity, corresponding to the difference between the initial visual acuity and the 3months one. The visual acuity is measured with monoyer scale and converted in log Mar.
Original Secondary Outcome: Same as current
Information By: Nantes University Hospital
Dates:
Date Received: March 13, 2014
Date Started: September 2014
Date Completion: September 2016
Last Updated: March 22, 2016
Last Verified: March 2016
